When posing for a photo, have you ever been asked to give the camera a big smile? Perhaps you've thought to yourself that a big smile is the only smile you can really give. Macrodontia is a form of gigantism that affects your teeth. All of your teeth might be excessively large, although it's more likely to be several teeth or even just the one. While your smile might be big (and your teeth might be perfectly healthy), the look of your smile can be uneven.